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RESEARCH AND REPORT ARTICLE: TRADITIONAL CHINESE MEDICINE AND NEURAL REGENERATION
Year : 2013  |  Volume : 8  |  Issue : 15  |  Page : 1383-1389

Gastrodin promotes the secretion of brain-derived neurotrophic factor in the injured spinal cord


Vertebral Column Ward, Department of Orthopedics, First Affiliated Hospital of Liaoning Medical University, Jinzhou 121000, Liaoning Province, China

Correspondence Address:
Xifan Mei
Professor, Masterís supervisor, Vertebral Column Ward, Department of Orthopedics, First Affiliated Hospital of Liaoning Medical University, Jinzhou 121000, Liaoning Province
China
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Source of Support: This project was financially supported by the National Natural Science Foundation of China, No. 81171799., Conflict of Interest: None


DOI: 10.3969/j.issn.1673-5374.2013.15.005

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Gastrodin, an active component of tall gastrodia tuber, is widely used in the treatment of dizziness, paralysis, epilepsy, stroke and dementia, and exhibits a neuroprotective effect. A rat model of spinal cord injury was established using Allen's method, and gastrodin was administered via the subarachnoid cavity and by intraperitoneal injection for 7 days. Results show that gastrodin promoted the secretion of brain-derived neurotrophic factor in rats with spinal cord injury. After gastrodin treatment, the maximum angle of the inclined plane test, and the Basso, Beattie and Bresnahan scores increased. Moreover, gastrodin improved neural tissue recovery in the injured spinal cord. These results demonstrate that gastrodin promotes the secretion of brain-derived neurotrophic factor, contributes to the recovery of neurological function, and protects neural cells against injury.

Research Highlights

(1) Gastrodin significantly contributes to the recovery of neurological function in rats with spinal cord injury.

(2) Gastrodin promotes the secretion of brain-derived neurotrophic factor in the injured spinal cord.

(3) Gastrodin can maintain a uniform distribution of brain-derived neurotrophic factor in the spinal cord tissue, and stabilize the microenvironment following spinal cord injury.



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