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REVIEW
Year : 2014  |  Volume : 9  |  Issue : 12  |  Page : 1210-1216

Autophagy: a double-edged sword for neuronal survival after cerebral ischemia


1 Department of Neurology, the Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China
2 Zhoupu Hospital, Pudong New District, Shanghai, China

Correspondence Address:
Kangyong Liu
Zhoupu Hospital, Pudong New District, Shanghai
China
Xiaojiang Sun
Department of Neurology, the Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai
China
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Source of Support: This work was supported by grants from the project of National Natural Science Foundation of China, No. 31171014 and 31371065; the project of Science and Technology Commission of Board of Health of Shanghai, China, No. 20134125; the Key Specialty (disease) Declaration of Pudong New Area's Health System., Conflict of Interest: None


DOI: 10.4103/1673-5374.135329

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Evidence suggests that autophagy may be a new therapeutic target for stroke, but whether activation of autophagy increases or decreases the rate of neuronal death is still under debate. This review summarizes the potential role and possible signaling pathway of autophagy in neuronal survival after cerebral ischemia and proposes that autophagy has dual effects.


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