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RESEARCH AND REPORT
Year : 2014  |  Volume : 9  |  Issue : 14  |  Page : 1351-1357

An inside-out vein graft filled with platelet-rich plasma for repair of a short sciatic nerve defect in rats


1 Department of Orthopedic Surgery, Seoul Paik Hospital, Inje University, Seoul, Korea
2 Department of Orthopedic Surgery, Korea University, Seoul, Korea
3 Department of Physical Medicine & Rehabilitation, Korea University, Seoul, Korea
4 Department of Anatomy, Korea University, Seoul, Korea
5 Biomedical Research Center, Korea Institute of Science and Technology, Seoul, Korea

Correspondence Address:
Jong Woong Park
Korea University Ansan Hospital, Gojan 1-Dong, Danwon-Gu, Ansan-Si, Gyeonggi-Do, 152-703
Korea
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Source of Support: This study was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology, No. 2011-0010429., Conflict of Interest: None


DOI: 10.4103/1673-5374.137587

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Platelet-rich plasma containing various growth factors can promote nerve regeneration. An inside-out vein graft can substitute nerve autograft to repair short nerve defects. It is hypothesized that an inside-out vein graft filled with platelet-rich plasma shows better effects in the repair of short sciatic nerve defects. In this study, an inside-out vein autograft filled with platelet-rich plasma was used to bridge a 10 mm-long sciatic nerve defect in rats. The sciatic nerve function of rats with an inside-out vein autograft filled with platelet-rich plasma was better improved than that of rats with a simple inside-out vein autograft. At 6 and 8 weeks, the sciatic nerve function of rats with an inside-out vein autograft filled with platelet-rich plasma was better than that of rats undergoing nerve autografting. Compared with the sciatic nerve repaired with a simple inside-out vein autograft, the number of myelinated axons was higher, axon diameter and myelin sheath were greater in the sciatic nerve repaired with an inside-out vein autograft filled with platelet-rich plasma and they were similar to those in the sciatic nerve repaired with nerve autograft. These findings suggest that an inside-out vein graft filled with platelet-rich plasma can substitute nerve autograft to repair short sciatic nerve defects.


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