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INVITED REVIEW
Year : 2014  |  Volume : 9  |  Issue : 19  |  Page : 1708-1711

Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson's disease


Department of Anatomy and Neuroscience, Biosciences Institute, University College Cork, Cork, Ireland

Correspondence Address:
Aideen M Sullivan
Department of Anatomy and Neuroscience, Biosciences Institute, University College Cork, Cork
Ireland
Gerard W O'Keeffe
Department of Anatomy and Neuroscience, Biosciences Institute, University College Cork, Cork
Ireland
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Source of Support: Studies in the authors' laboratories are supported by grants from the Irish Research Council (R13702 and R15897; SVH/AS/G'OK), the Health Research Board of Ireland (HRA/2009/127; GO'K/AS) and Science Foundation Ireland (10/RFP/NES2786; GO'K)., Conflict of Interest: None


DOI: 10.4103/1673-5374.143410

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Neuroprotection and neuroregeneration are two of the most promising disease-modifying therapies for the incurable and widespread Parkinson's disease. In Parkinson's disease, progressive degeneration of nigrostriatal dopaminergic neurons causes debilitating motor symptoms. Neurotrophic factors play important regulatory roles in the development, survival and maintenance of specific neuronal populations. These factors have the potential to slow down, halt or reverse the loss of nigrostriatal dopaminergic neurons in Parkinson's disease. Several neurotrophic factors have been investigated in this regard. This review article discusses the neurodevelopmental roles and therapeutic potential of three dopaminergic neurotrophic factors: glial cell line-derived neurotrophic factor, neurturin and growth/differentiation factor 5.


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