• Users Online: 7481
  • Home
  • Print this page
  • Email this page
EVIDENCE-BASED MEDICINE
Year : 2014  |  Volume : 9  |  Issue : 1  |  Page : 101-110

Critical illness polyneuropathy and myopathy: a systematic review


1 Department of Neurology, the First Bethune Hospital, Jilin University; Department of Neurology, the Second Part, the First Bethune Hospital, Jilin University, Changchun 130021, Jilin Province, China, China
2 Department of Neurology, the First Bethune Hospital, Jilin University, Changchun 130021, Jilin Province, China; Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, MA, USA, China
3 Department of Radiotherapy, Oncology Center, the First Bethune Hospital, Jilin University, Changchun 130021, Jilin Province, China, China
4 Department of Vascular Surgery, People’s Hospital of Jilin Province, Changchun 130000, Jilin Province, China, China
5 Department of Neurology, the First Bethune Hospital, Jilin University, Changchun 130021, Jilin Province, China, China

Correspondence Address:
Hongliang Zhang
Department of Neurology, the First Bethune Hospital, Jilin University, Xinmin street 71#, Changchun 130021, Jilin Province
China
Login to access the Email id

Source of Support: This work was supported by grants from China Scholarship Council, No. 2008102056; the National Natural Science Foundation of China, No. 81241147., Conflict of Interest: None


DOI: 10.4103/1673-5374.125337

Rights and Permissions

Critical illness polyneuropathy and critical illness myopathy are frequent complications of severe illness that involve sensorimotor axons and skeletal muscles, respectively. Clinically, they manifest as limb and respiratory muscle weakness. Critical illness polyneuropathy/myopathy in isolation or combination increases intensive care unit morbidity via the inability or difficulty in weaning these patients off mechanical ventilation. Many patients continue to suffer from decreased exercise capacity and compromised quality of life for months to years after the acute event. Substantial progress has been made lately in the understanding of the pathophysiology of critical illness polyneuropathy and myopathy. Clinical and ancillary test results should be carefully interpreted to differentiate critical illness polyneuropathy/myopathy from similar weaknesses in this patient population. The present review is aimed at providing the latest knowledge concerning the pathophysiology of critical illness polyneuropathy/myopathy along with relevant clinical, diagnostic, differentiating, and treatment information for this debilitating neurological disease.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed8315    
    Printed92    
    Emailed5    
    PDF Downloaded2611    
    Comments [Add]    
    Cited by others 23    

Recommend this journal