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Year : 2014  |  Volume : 9  |  Issue : 5  |  Page : 463-473

Apolipoprotein E mimetic peptide protects against diffuse brain injury

1 College of Rehabilitation, Hebei United University, Tangshan, Hebei Province, China
2 Affiliated Hospital of Hebei United University, Tangshan, Hebei Province, China

Correspondence Address:
Yaning Zhao
College of Rehabilitation, Hebei United University, Tangshan 063000, Hebei Province
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Source of Support: Funding: This study was supported by Scientific Research and Development Plan of Hebei Province, No. 20276102D; Key Project of Scientific Research in Universities of Hebei Province in China, No. ZD2010106., Conflict of Interest: None

DOI: 10.4103/1673-5374.130060

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Apolipoprotein E plays a crucial role in inhibiting chronic neurodegenerative processes. However, its impact on neurological function following diffuse brain injury is still unclear. This study was designed to evaluate the therapeutic effects and mechanisms of action of apolipoprotein E mimetic peptide on diffuse brain injury. Apolipoprotein E mimetic peptide was administered into the caudal vein of rats with diffuse brain injury before and after injury. We found that apolipoprotein E mimetic peptide significantly decreased the number of apoptotic neurons, reduced extracellular signal-regulated kinase1/2 phosphorylation, down-regulated Bax and cytochrome c expression, decreased malondialdehyde content, and increased superoxide dismutase activity in a dose-dependent manner. These experimental findings demonstrate that apolipoprotein E mimetic peptide improves learning and memory function and protects against diffuse brain injury-induced apoptosis by inhibiting the extracellular signal-regulated kinase1/2-Bax mitochondrial apoptotic pathway.

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