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TECHNICAL UPDATES
Year : 2014  |  Volume : 9  |  Issue : 5  |  Page : 534-539

Adaptive and regulatory mechanisms in aged rats with postoperative cognitive dysfunction


1 Department of Anesthesiology, Affiliated Qianfoshan Hospital, Shandong University, Jinan, Shandong Province; Department of Anesthesiology, Shaoxing People's Hospital, Shaoxing, Zhejiang Province, China
2 Department of Anesthesiology, Shaoxing People's Hospital, Shaoxing, Zhejiang Province, China
3 Department of Anesthesiology, Qingdao Municipal Hospital, Qingdao, Shandong Province, China
4 Department of Anesthesiology, Affiliated Qianfoshan Hospital, Shandong University, Jinan, Shandong Province, China

Correspondence Address:
M.D. Yuelan Wang
Department of Anesthesiology, Affiliated Qianfoshan Hospital, Shandong University, Jinan 250014, Shandong Province
China
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Source of Support: None, Conflict of Interest: None


Read associated Erratum: Erratum with this article

DOI: 10.4103/1673-5374.130084

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Inflammation may play a role in postoperative cognitive dysfunction. 5′ Adenosine monophosphate-activated protein kinase, nuclear factor-kappa B, interleukin-1β, and tumor necrosis factor-α are involved in inflammation. Therefore, these inflammatory mediators may be involved in postoperative cognitive dysfunction. Western immunoblot analysis revealed 5′ adenosine monophosphate-activated protein kinase and nuclear factor-kappa B in the hippocampus of aged rats were increased 1-7 days after splenectomy. Moreover, interleukin-1β and tumor necrosis factor-α were upregulated and gradually decreased. Therefore, these inflammatory mediators may participate in the splenectomy model of postoperative cognitive dysfunction in aged rats.


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