• Users Online: 597
  • Home
  • Print this page
  • Email this page
INVITED REVIEW
Year : 2014  |  Volume : 9  |  Issue : 6  |  Page : 565-574

Mechanisms of secondary degeneration after partial optic nerve transection


1 Department of Ophthalmology; State Key Laboratory of Brain and Cognitive Science, the University of Hong Kong, Hong Kong Special Administrative Region, China
2 GHM Institute of CNS Regeneration; Guangdong Key Laboratory of Brain Function and Diseases, Jinan University, Guangzhou, Guangdong Province, China
3 Department of Ophthalmology; State Key Laboratory of Brain and Cognitive Science, the University of Hong Kong, Hong Kong Special Administrative Region; GHM Institute of CNS Regeneration; Guangdong Key Laboratory of Brain Function and Diseases, Jinan University, Guangzhou, Guangdong Province, China

Correspondence Address:
Ph.D. Kwok-Fai So
Chair Professor, Department of Ophthalmology, the University of Hong Kong, Hong Kong Special Administrative Region
China
Login to access the Email id

Source of Support: Funding: The work described in this paper was substantially supported by a grant from the Research Grants Council of the Hong Kong Special Administrative Region, China (HKU 776109M). In addition, this work was partially supported by the Fundamental Research Funds for the Central Universities Grant 21609101., Conflict of Interest: None


DOI: 10.4103/1673-5374.130093

Rights and Permissions

Secondary degeneration occurs commonly in the central nervous system after traumatic injuries and following acute and chronic diseases, including glaucoma. A constellation of mechanisms have been shown to be associated with secondary degeneration including apoptosis, necrosis, autophagy, oxidative stress, excitotoxicity, derangements in ionic homeostasis and calcium influx. Glial cells, such as microglia, astrocytes and oligodendrocytes, have also been demonstrated to take part in the process of secondary injury. Partial optic nerve transection is a useful model which was established about 13 years ago. The merit of this model compared with other optic nerve injury models used for glaucoma study, including complete optic nerve transection model and optic nerve crush model, is the possibility to separate primary degeneration from secondary degeneration in location. Therefore, it provides a good tool for the study of secondary degeneration. This review will focus on the research progress of the mechanisms of secondary degeneration using partial optic nerve transection model.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2306    
    Printed28    
    Emailed0    
    PDF Downloaded639    
    Comments [Add]    
    Cited by others 19    

Recommend this journal