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RESEARCH AND REPORT
Year : 2014  |  Volume : 9  |  Issue : 9  |  Page : 919-923

Intravenous transplantation of bone marrow mesenchymal stem cells promotes neural regeneration after traumatic brain injury


1 Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2 Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran

Correspondence Address:
Ph.D. Mohammad Ali Khalili
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd
Iran
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Source of Support: This study was supported by research center from Shahid Sadoughi University of Medical Sciences, Yazd, Iran, Conflict of Interest: None


DOI: 10.4103/1673-5374.133133

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To investigate the supplement of lost nerve cells in rats with traumatic brain injury by intravenous administration of allogenic bone marrow mesenchymal stem cells, this study established a Wistar rat model of traumatic brain injury by weight drop impact acceleration method and administered 3 × 10 6 rat bone marrow mesenchymal stem cells via the lateral tail vein. At 14 days after cell transplantation, bone marrow mesenchymal stem cells differentiated into neurons and astrocytes in injured rat cerebral cortex and rat neurological function was improved significantly. These findings suggest that intravenously administered bone marrow mesenchymal stem cells can promote nerve cell regeneration in injured cerebral cortex, which supplement the lost nerve cells.


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