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INVITED REVIEW
Year : 2017  |  Volume : 12  |  Issue : 7  |  Page : 1024-1027

BDNF pro-peptide: a novel synaptic modulator generated as an N-terminal fragment from the BDNF precursor by proteolytic processing


1 Biomedical Research Inst. (BMD), National Institute of Advanced Industrial Science and Technology (AIST), Osaka; Core Research for Evolutional Science and Technology (CREST), Science and Technology Agency (JST), Kawaguchi, Japan
2 Laboratory of Nutritional Brain Science, Department of Food Science and Nutrition, Mukogawa Women's University, Hyogo, Japan
3 Biomedical Research Inst. (BMD), National Institute of Advanced Industrial Science and Technology (AIST), Osaka; Core Research for Evolutional Science and Technology (CREST), Science and Technology Agency (JST), Kawaguchi; Graduate School of Frontier Bioscience, Osaka University, Suita, Japan

Correspondence Address:
Masami Kojima
Biomedical Research Inst. (BMD), National Institute of Advanced Industrial Science and Technology (AIST), Osaka; Core Research for Evolutional Science and Technology (CREST), Science and Technology Agency (JST), Kawaguchi; Graduate School of Frontier Bioscience, Osaka University, Suita
Japan
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Source of Support: This work was supported by a Grant-in-Aid for Scientific Research on Priority Areas (Elucidation of neural network function in the brain) from the Ministry of Education, Culture, Sports, Science and Technology of Japan: KAKENHI Grant-in-Aid for Scientific Research (17K07073 and 22500305) (MK); Japan Science and Technology Agency; and Core Research for Evolutional Science and Technology (MK)., Conflict of Interest: None


DOI: 10.4103/1673-5374.211173

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Most growth factors are initially synthesized as precursors and it was cleaved into bioactive mature domain and pro-domain. However, compared with the expression and function of bioactive mature domain, the biological role of the pro-domain is poorly understood. Unexpectedly, we found that the pro-domain (or pro-peptide) of brain-derived neurotrophic factor (BDNF), which is well-known neurotrophic factor in brain, has a potential ability to facilitate hippocampal long-term depression. Furthermore, a BDNF polymorphism Val66Met, which substitute valine into methionine at 66 amino acid, impacted the biological activity of the BDNF pro-peptide. We lastly discuss the possible roles of BDNF and its pro-peptide in the generation of neural stem cells and progress of ischemia.


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