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REVIEW
Year : 2019  |  Volume : 14  |  Issue : 11  |  Page : 1851-1857

Mesenchymal stromal cell therapy for damaged retinal ganglion cells, is gold all that glitters?


1 Grupo de Oftalmología Experimental, Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca); Department of Talmología, Universidad de Murcia, Murcia, Spain
2 Unidad de Terapia Celular y Trasplante Hematopoyético, Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca); Department of Medicina Interna, Universidad de Murcia, Murcia, Spain

Correspondence Address:
Marta Agudo-Barriuso
Grupo de Oftalmología Experimental, Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca); Department of Talmología, Universidad de Murcia, Murcia
Spain
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Source of Support: This work was supported by the Spanish Ministry of Economy and Competitiveness, Instituto de Salud Carlos III (ISCIII), Fondo Europeo de Desarrollo Regional “Una Manera de Hacer Europa” (SAF2015-67643-P to MVS and PI16/00031 to MAB) and Fundación Séneca, Agencia de Ciencia y Tecnología Región de Murcia (19881/GERM/15 to MVS), Conflict of Interest: None


DOI: 10.4103/1673-5374.259601

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Mesenchymal stromal cells are an excellent source of stem cells because they are isolated from adult tissues or perinatal derivatives, avoiding the ethical concerns that encumber embryonic stem cells. In preclinical models, it has been shown that mesenchymal stromal cells have neuroprotective and immunomodulatory properties, both of which are ideal for central nervous system treatment and repair. Here we will review the current literature on mesenchymal stromal cells, focusing on bone marrow mesenchymal stromal cells, adipose-derived mesenchymal stromal cells and mesenchymal stromal cells from the umbilical cord stroma, i.e., Wharton’s jelly mesenchymal stromal cells. Finally, we will discuss the use of these cells to alleviate retinal ganglion cell degeneration following axonal trauma.


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