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Year : 2019  |  Volume : 14  |  Issue : 12  |  Page : 2063-2066

Turning to myelin turnover

Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany

Correspondence Address:
Hauke B Werner
Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen
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Source of Support: This work was supported by the Deutsche Forschungsgemeinschaft (DFG, WE2720/2-2 and WE2720/4-1, both to HBW), Conflict of Interest: None

DOI: 10.4103/1673-5374.262569

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Neural plasticity in the adult central nervous system involves the adaptation of myelination, including the formation of novel myelin sheaths by adult-born oligodendrocytes. Yet, mature oligodendrocytes slowly but constantly turn over their pre-existing myelin sheaths, thereby establishing an equilibrium of replenishment and degradation that may also be subject to adaptation with consequences for nerve conduction velocity. In this short review we highlight selected approaches to the normal turnover of adult myelin in vivo, from injecting radioactive precursors of myelin constituents in the 1960s to current strategies involving isotope labeling and tamoxifen-induced gene targeting.

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