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REVIEW
Year : 2019  |  Volume : 14  |  Issue : 8  |  Page : 1293-1308

Tandem pore TWIK-related potassium channels and neuroprotection


Laboratory of Neuroscience, Biomedical Research Center (CINBIO), University of Vigo, Vigo, Galicia, Spain

Correspondence Address:
Diego Fernández-Fernández
Laboratory of Neuroscience, Biomedical Research Center (CINBIO), University of Vigo, Vigo, Galicia
Spain
J Antonio Lamas
Laboratory of Neuroscience, Biomedical Research Center (CINBIO), University of Vigo, Vigo, Galicia
Spain
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Source of Support: This work was supported by grants to JAL from the Spanish Government: Secretaría de Estado de Investigación, Desarrollo e Innovación (MINECO, BFU2014-58999-P), Galician Government: Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia (GPC2015/022) and European Regional Development Fund (FP7-316265-BIOCAPS). Partially supported with Fondo Europeo de Desarrollo Regional Funds, Conflict of Interest: None


DOI: 10.4103/1673-5374.253506

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TWIK-related potassium channels (TREK) belong to a subfamily of the two-pore domain potassium channels family with three members, TREK1, TREK2 and TWIK-related arachidonic acid-activated potassium channels. The two-pore domain potassium channels is the last big family of channels being discovered, therefore it is not surprising that most of the information we know about TREK channels predominantly comes from the study of heterologously expressed channels. Notwithstanding, in this review we pay special attention to the limited amount of information available on native TREK-like channels and real neurons in relation to neuroprotection. Mainly we focus on the role of free fatty acids, lysophospholipids and other neuroprotective agents like riluzole in the modulation of TREK channels, emphasizing on how important this modulation may be for the development of new therapies against neuropathic pain, depression, schizophrenia, epilepsy, ischemia and cardiac complications.


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