Close
  Indian J Med Microbiol
 

Figure 2: Effect of aging on miRNA biogenesis. Mature miRNAs control cellular homeostasis, mediate stress response and inhibit apoptosis pathways. With aging, Dicer levels are down-regulated and miRNA processing activity of Dicer complex is reduced, leading to an increased vulnerability to stressors. This mechanism may contribute to age-related loss of nigral dopaminergic neurons in PD.

Figure 2: Effect of aging on miRNA biogenesis. 
Mature miRNAs control cellular homeostasis, mediate stress response and inhibit apoptosis pathways. With aging, Dicer levels are down-regulated and miRNA processing activity of Dicer complex is reduced, leading to an increased vulnerability to stressors. This mechanism may contribute to age-related loss of nigral dopaminergic neurons in PD.