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RESEARCH AND REPORT: STEM CELLS AND NEURAL REGENERATION
Year : 2012  |  Volume : 7  |  Issue : 22  |  Page : 1703-1708

Sonic hedgehog elevates N-myc gene expression in neural stem cells


1 Department of Neurosurgery, First Affiliated Hospital, Dalian Medical University, Dalian 116011, Liaoning Province, China
2 Chinese Academy of Medical Sciences, Department of Neurosurgery, Peking Union Medical College Hospital, Beijing 100730, China

Correspondence Address:
Bo Zhang
Department of Neurosurgery, First Affili-ated Hospital, Dalian Medical University, Dalian 116011, Liaoning Province
China
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Source of Support: This project was funded by the National Natural Science Foundation of China, No.81171401; Science and Technology Development Program of Dalian City, No. 2008J99JH268; the Scientific Research Program of Higher Learning School of Department of Education of Liaoning Province, No. L20100108., Conflict of Interest: None


DOI: 10.3969/j.issn.1673-5374.2012.22.004

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Proliferation of neural stem cells is regulated by the secreted signaling molecule sonic hedgehog. In this study, neural stem cells were infected with recombinant adeno-associated virus expressing sonic hedgehog-N-enhanced green fluorescent protein. The results showed that overexpression of sonic hedgehog in neural stem cells induced the increased expression of Gli1 and N-myc, a target gene of sonic hedgehog. These findings suggest that N-myc is a direct downstream target of the sonic hedgehog signal pathway in neural stem cells. Sonic hedgehog and N-myc are important mediators of sonic hedgehog-induced proliferation of neural stem cells. Research Highlights
  1. Neural stem cells were infected with recombinant adeno-associated virus expressing sonic hedgehog-N-enhanced green fluorescent protein.
  2. We verified that N-myc is a direct downstream target of the sonic hedgehog signal pathway in neural stem cells.
Abbreviations SHH, sonic hedgehog; EGFP, enhanced green fluorescent protein; rAAV, recombinant adeno-associated virus


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