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BRAIN INJURY AND NEURAL REGENERATION
Year : 2012  |  Volume : 7  |  Issue : 22  |  Page : 1715-1721

Neuroprotective effects of bovine colostrum on intracerebral hemorrhage-induced apoptotic neuronal cell death in rats


1 Department of Physiology, College of Medicine, Kyung Hee University, Seoul 130-701, Korea
2 Department of Emergency Medicine, College of Medicine, Kyung Hee University, Seoul 130-701, Korea
3 Department of Emergency Medicine, Korea University Ansan Hospital, Ansan 425-707, Korea

Correspondence Address:
Hanjin Cho
Department of Emergency Medicine, Korea University Ansan Hospital, #516 Gojan-dong, Danwon-gu, Ansan 425-707
Korea
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Source of Support: None, Conflict of Interest: None


DOI: 10.3969/j.issn.1673-5374.2012.22.006

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Brain cell death after intracerebral hemorrhage may be mediated in part by an apoptotic mechanism. Colostrum is the first milk produced by mammals for their young. It plays an important role in protection and development by providing various antibodies, growth factors and nutrients, and has been used for various diseases in many countries. In the present study, we investigated the anti-apoptotic effects of bovine colostrum using organotypic hippocampal slice cultures and an intracerebral hemorrhage animal model. We performed densitometric measurements of propidium iodide uptake, a step-down avoidance task, Nissl staining, and caspase-3 immunohistochemistry. The present results revealed that colostrum treatment significantly suppressed N-methyl-D-aspartic acid-induced neuronal cell death in the rat hippocampus. Moreover, colostrum treatment improved short-term memory by suppressing hemorrhage-induced apoptotic neuronal cell death and decreasing the volume of the lesion induced by intracerebral hemorrhage in the rat hippocampus. These results suggest that colostrum may have a beneficial role in recovering brain function following hemorrhagic stroke by suppressing apoptotic cell death. Research Highlights
  1. In vitro experiment results confirmed that bovine colostrum can inhibit N-methyl-D-aspartic acid-induced neuronal cell death in the rat hippocampus.
  2. In vivo experimental results confirmed that bovine colostrum can inhibit intracerebral hemorrhage-induced neuronal cell death, decrease caspase-3 expression, and reduce the size of intracerebral hemorrhage-induced lesions in the hippocampus, and improve the cognitive function of rats with intracerebral hemorrhage.
Abbreviation NMDA, N-methyl-D-aspartic acid


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