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BRAIN INJURY AND NEURAL REGENERATION
Year : 2012  |  Volume : 7  |  Issue : 22  |  Page : 1722-1728

5-hydroxymethyl-2-furfural prolongs survival and inhibits oxidative stress in a mouse model of forebrain ischemia


1 Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Beijing Geriatric Medical Research Center, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053; Department of Physiology, Jining Medical University, Jining 272067, Shandong Province, China
2 Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Beijing Geriatric Medical Research Center, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, China

Correspondence Address:
Lin Li
Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Beijing Geriatric Medical Research Center, Key Laboratory for Neuro-degenerative Diseases of Ministry of Education, Beijing 100053
China
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Source of Support: This project was supported by the National Basic Research Program of China (973 Program), No. 2003CB517104; the National Natural Science Foundation of China, No. 30973513; Beijing Municipal Science and Technology Program, No. D0206001043191; the Natural Science Foundation of Beijing, No.7112061; Beijing Key Foundation of Traditional Chinese Medicine, No. KJTS2011-04; and Beijing Health and Technical Personal of High-Level Plan, No. 2009-3-66., Conflict of Interest: None


DOI: 10.3969/j.issn.1673-5374.2012.22.007

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In the present study, we hypothesized that 5-hydroxymethyl-2-furfural could attenuate ischemic brain damage by reducing oxidative injury. Thus, mice were subjected to bilateral common carotid artery occlusion to establish a model of permanent forebrain ischemia. The mice were intraperitoneally injected with 5-hydroxymethyl-2-furfural 30 minutes before ischemia or 5 minutes after ischemia. The survival time of mice injected with 5-hydroxymethyl-2-furfural was longer compared with untreated mice. The mice subjected to ischemia for 30 minutes and reperfusion for 5 minutes were intraperitoneally injected with 5-hydroxymethyl-2-furfural 5 minutes prior to reperfusion, which increased superoxide dismutase content and reduced malondialdehyde content, similar to the effects of Edaravone, a hydroxyl radical scavenger used for the treatment of stroke. These findings indicate that intraperitoneal injection of 5-hydroxymethyl-2-furfural can prolong the survival of mice with permanent forebrain ischemia. This outcome may be mediated by its antioxidative effects. Research Highlights
  1. 5-hydroxymethyl-2-furfural pretreatment and treatment prolonged the survival of mice with permanent forebrain ischemia. In addition, these effects were associated with increased brain superoxide dismutase activity and reduced malondialdehyde content.
  2. The ability of 5-hydroxymethyl-2-furfural to prolong survival may be mediated by these antioxidative effects.
Abbreviations BCAO, bilateral common carotid artery occlusion; MDA, malondialdehyde; SOD, superoxide dismutase


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