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BRAIN INJURY AND NEURAL REGENERATION
Year : 2012  |  Volume : 7  |  Issue : 22  |  Page : 1729-1735

Early hyperbaric oxygen therapy inhibits aquaporin 4 and adrenocorticotropic hormone expression in the pituitary gland of rabbits with blast-induced craniocerebral injury


Department of Neurosurgery, the 105 Hospital of Chinese PLA, Hefei 230032, Anhui Province, China

Correspondence Address:
Jiachuan Liu
vDepartment of Neuro-surgery, the 105 Hospital of Chinese PLA, Hefei 230032, Anhui Province
China
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Source of Support: This study was supported by the Eleventh-Five Major Subjects of Nanjing Military Area Command, No. 06Z19; and the Military Medical Science and Technology Innovation Foundation in 2009, No. 09Z009., Conflict of Interest: None


DOI: 10.3969/j.issn.1673-5374.2012.22.008

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In the present study, rabbits were treated with hyperbaric oxygen for 1 hour after detonator-blast- induced craniocerebral injury. Immunohistochemistry showed significantly reduced aquaporin 4 expression and adrenocorticotropic hormone expression in the pituitary gland of rabbits with craniocerebral injury. Aquaporin 4 expression was positively correlated with adrenocorticotropic hormone expression. These findings indicate that early hyperbaric oxygen therapy may suppress adrenocorticotropic hormone secretion by inhibiting aquaporin 4 expression. Research Highlights Early hyperbaric oxygen suppresses adrenocorticotropic hormone secretion in the pituitary gland by inhibiting aquaporin 4 expression


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