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REVIEW
Year : 2012  |  Volume : 7  |  Issue : 22  |  Page : 1737-1743

Thrombospondins and synaptogenesis


Department of Orthopedics, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, Guangdong Province, China

Correspondence Address:
Weitao Guo
Department of Orthopedics, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, Guangdong Province
China
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Source of Support: This study was supported by the Natural Science Foundation of Guangdong Province, No. S2011010004096; the Medical Scientific Research Foundation of Guangdong Province, No. A2010431; A2009477., Conflict of Interest: None


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Here, we review research on the mechanisms underlying the ability of thrombospondin to promote synaptogenesis and examine its role in central nervous system diseases and drug actions. Thrombospondin secreted by glial cells plays a critical role in synaptogenesis and maintains synapse stability. Thrombospondin regulates synaptogenesis through receptor α2δ-1 and neuroligin 1, and promotes the proliferation and differentiation of neural progenitor cells. It also participates in synaptic remodeling following injury and in the action of some nervous system drugs. Research Highlights
  1. This review summarizes the effects and underlying mechanisms of action of thrombospondin in synaptogenesis.
  2. Thrombospondin regulates synaptogenesis through receptor α2δ-1 and neuroligin 1, and promotes the proliferation and differentiation of neural progenitor cells.
  3. Thrombospondin also participates in synaptic remodeling following injury and in the action of some nervous system drugs.
Abbreviations TSP, thrombospondin; NPCs, neural progenitor cells; CNS, central nervous system; RGCs, retinal ganglion cells; EGF, epidermal growth factor


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