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BRAIN INJURY AND NEURAL REGENERATION
Year : 2013  |  Volume : 8  |  Issue : 4  |  Page : 338-345

Aquaporin 4 expression and ultrastructure of the blood-brain barrier following cerebral contusion injury


1 Department of Neurosurgery, Deyang People’s Hospital, Deyang 618000, Sichuan Province, China
2 Department of Neurosurgery, Deyang People’s Hospital, Deyang 618000; Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China

Correspondence Address:
Hong Xu
Master, Chief physician, Department of Neurosurgery, Deyang People’s Hospital, Deyang 618000, Sichuan Province
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.3969/j.issn.1673-5374.2013.04.006

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This study aimed to investigate aquaporin 4 expression and the ultrastructure of the blood-brain barrier at 2-72 hours following cerebral contusion injury, and correlate these changes to the formation of brain edema. Results revealed that at 2 hours after cerebral contusion and laceration injury, aquaporin 4 expression significantly increased, brain water content and blood-brain barrier permeability increased, and the number of pinocytotic vesicles in cerebral microvascular endothelial cells increased. In addition, the mitochondrial accumulation was observed. As contusion and laceration injury became aggravated, aquaporin 4 expression continued to increase, brain water content and blood-brain barrier permeability gradually increased, brain capillary endothelial cells and astrocytes swelled, and capillary basement membrane injury gradually increased. The above changes were most apparent at 12 hours after injury, after which they gradually attenuated. Aquaporin 4 expression positively correlated with brain water content and the blood-brain barrier index. Our experimental findings indicate that increasing aquaporin 4 expression and blood-brain barrier permeability after cerebral contusion and laceration injury in humans is involved in the formation of brain edema.
Research Highlights (1) Aquaporin 4 expression, brain water content, and blood-brain barrier index were upregulated at early stages following cerebral contusion and laceration injury in humans. (2) Aquaporin 4 expression positively correlated with brain water content and blood-brain barrier permeability at early stages following cerebral contusion and laceration injury in humans.


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