• Users Online: 2704
  • Home
  • Print this page
  • Email this page
RESEARCH AND REPORT
Year : 2014  |  Volume : 9  |  Issue : 10  |  Page : 1003-1013

Intraspinal transplantation of motoneuron-like cell combined with delivery of polymer-based glial cell line-derived neurotrophic factor for repair of spinal cord contusion injury


Shefa Neuroscience Research Center at Khatam Al-Anbia Hospital, Tehran, Iran

Correspondence Address:
Taki Tiraihi
Department of Anatomical Sciences, Faculty of Medical Sciences, Tarbiat Modares University, Jalal El Ahmed express way, P.O. Box 14155-4838, Tehran
Iran
Login to access the Email id

Source of Support: The project was funded by Shefa Neurosciences Research Center at Khatam Al-Anbia Hospital, Tehran, Iran (Grant # 86-N-105)., Conflict of Interest: None


DOI: 10.4103/1673-5374.133159

Rights and Permissions

To evaluate the effects of glial cell line-derived neurotrophic factor transplantation combined with adipose-derived stem cells-transdifferentiated motoneuron delivery on spinal cord contusion injury, we developed rat models of spinal cord contusion injury, 7 days later, injected adipose-derived stem cells-transdifferentiated motoneurons into the epicenter, rostral and caudal regions of the impact site and simultaneously transplanted glial cell line-derived neurotrophic factor-gelfoam complex into the myelin sheath. Motoneuron-like cell transplantation combined with glial cell line-derived neurotrophic factor delivery reduced cavity formations and increased cell density in the transplantation site. The combined therapy exhibited superior promoting effects on recovery of motor function to transplantation of glial cell line-derived neurotrophic factor, adipose-derived stem cells or motoneurons alone. These findings suggest that motoneuron-like cell transplantation combined with glial cell line-derived neurotrophic factor delivery holds a great promise for repair of spinal cord injury.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2608    
    Printed33    
    Emailed0    
    PDF Downloaded403    
    Comments [Add]    
    Cited by others 6    

Recommend this journal