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RESEARCH AND REPORT
Year : 2014  |  Volume : 9  |  Issue : 10  |  Page : 1020-1024

L-carnitine alleviates sciatic nerve crush injury in rats: functional and electron microscopy assessments


1 Department of Medical Education, Faculty of Medicine, Ataturk University, Yakutiye, Erzurum, Turkey
2 Department of Family Medicine, Faculty of Medicine, Ataturk University, Yakutiye, Erzurum, Turkey
3 Department of Orthopedics and Traumatology, Faculty of Medicine, Ataturk University, Yakutiye, Erzurum, Turkey
4 Department of Pharmacology, Faculty of Medicine, Ataturk University, Yakutiye, Erzurum, Turkey
5 Department of Pharmacology, Faculty of Pharmacy, Agrı University, Agrı, Turkey
6 Department of Biochemistry, Faculty of Pharmacy, Agrı University, Agrı, Turkey
7 Department of Emergency Medicine, Faculty of Medicine, Ataturk University, Yakutiye, Erzurum, Turkey
8 Department of Histology and Embryology, Faculty of Medicine, Ataturk University, Yakutiye, Erzurum, Turkey

Correspondence Address:
Ümmü Zeynep Avsar
Department of Medical Education, Faculty of Medicine, Ataturk University, Erzurum 25240
Turkey
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Source of Support: This study was supported by a grant from Ataturk University Scientific Experimental Project Office to Project Number 2012/07., Conflict of Interest: None


DOI: 10.4103/1673-5374.133163

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Several studies have demonstrated that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats with diabetes mellitus. It is hypothesized that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats. Rat sciatic nerve was crush injured by a forceps and exhibited degenerative changes. After intragastric administration of 50 and 100 mg/kg L-carnitine for 30 days, axon area, myelin sheath area, axon diameter, myelin sheath diameter, and numerical density of the myelinated axons of injured sciatic nerve were similar to normal, and the function of injured sciatic nerve also improved significantly. These findings suggest that L-carnitine exhibits neuroprotective effects on sciatic nerve crush injury in rats.


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