• Users Online: 786
  • Home
  • Print this page
  • Email this page
RESEARCH AND REPORT
Year : 2014  |  Volume : 9  |  Issue : 10  |  Page : 1025-1030

Intranasal nerve growth factor bypasses the blood-brain barrier and affects spinal cord neurons in spinal cord injury


1 Cellular Biology and Neurobiology Institute, National Research Council (CNR), Rome, Italy
2 Maria Rosaria Maglione Foundation Onlus, Napoli, Italy
3 Intitute of Translational Pharmacology, National Research Council (CNR), Rome, Italy

Correspondence Address:
Luigi Aloe
Cellular Biology and Neurobiology Institute, National Research Council (CNR), Via del Fosso di Fiorano 64/65, 00143 Rome
Italy
Login to access the Email id

Source of Support: This study was supported by Proj. PRIN prot. 2007AF3XH4_005, "Fondazione Cassa di Risparmio di Roma", and "Ministero della Salute" Grant No. RF-FGB-2005-150198., Conflict of Interest: None


DOI: 10.4103/1673-5374.133161

Rights and Permissions

The purpose of this work was to investigate whether, by intranasal administration, the nerve growth factor bypasses the blood-brain barrier and turns over the spinal cord neurons and if such therapeutic approach could be of value in the treatment of spinal cord injury. Adult Sprague-Dawley rats with intact and injured spinal cord received daily intranasal nerve growth factor administration in both nostrils for 1 day or for 3 consecutive weeks. We found an increased content of nerve growth factor and enhanced expression of nerve growth factor receptor in the spinal cord 24 hours after a single intranasal administration of nerve growth factor in healthy rats, while daily treatment for 3 weeks in a model of spinal cord injury improved the deficits in locomotor behaviour and increased spinal content of both nerve growth factor and nerve growth factor receptors. These outcomes suggest that the intranasal nerve growth factor bypasses blood-brain barrier and affects spinal cord neurons in spinal cord injury. They also suggest exploiting the possible therapeutic role of intranasally delivered nerve growth factor for the neuroprotection of damaged spinal nerve cells.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2365    
    Printed27    
    Emailed0    
    PDF Downloaded354    
    Comments [Add]    
    Cited by others 12    

Recommend this journal