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INVITED REVIEW
Year : 2014  |  Volume : 9  |  Issue : 16  |  Page : 1506-1508

Possible protective action of neurotrophic factors and natural compounds against common neurodegenerative diseases


Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo, Japan

Correspondence Address:
Tadahiro Numakawa
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo, 187-8502
Japan
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Source of Support: This study was supported by the grant from Grant-in-Aid for Scientific Research (B) (JSPS KAKENHI Grant Number 24300139), and for Challenging Exploratory Research (JSPS KAKENHI Grant Number 25640019) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan., Conflict of Interest: None


DOI: 10.4103/1673-5374.139474

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It has been suggested that altered levels/function of brain-derived neurotrophic factor (BDNF) play a role in the pathophysiology of neurodegenerative diseases including Alzheimer's disease. BDNF positively contributes to neural survival and synapse maintenance via stimulating its high affinity receptor TrkB, making upregulation of BDNF and/or activation of BDNF-related intracellular signaling an attractive approach to treating neurodegenerative diseases. In this short review, I briefly introduce small natural compounds such as flavonoids that successfully increase activation of the BDNF system and discuss their beneficial effects against neurodegeneration.


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