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INVITED REVIEW
Year : 2014  |  Volume : 9  |  Issue : 16  |  Page : 1514-1517

Effects of naringin, a flavanone glycoside in grapefruits and citrus fruits, on the nigrostriatal dopaminergic projection in the adult brain


1 Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu, Korea
2 School of Life Sciences; BK21 plus KNU Creative BioResearch Group; Institute of Life Science & Biotechnology; Brain Science and Engineering Institute, Kyungpook National University, Daegu, Korea

Correspondence Address:
Sang Ryong Kim
School of Life Sciences, Kyungpook National University, Daegu, 702-701
Korea
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Source of Support: This research was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government, No. 2008-0061888 and 2012R1A1A1039140., Conflict of Interest: None


DOI: 10.4103/1673-5374.139476

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Recently, we have demonstrated the ability of naringin, a well-known flavanone glycoside of grapefruits and citrus fruits, to prevent neurodegeneration in a neurotoxin model of Parkinson's disease. Intraperitoneal injection of naringin protected the nigrostriatal dopaminergic projection by increasing glial cell line-derived neurotrophic factor expression and decreasing the level of tumor necrosis factor-alpha in dopaminergic neurons and microglia, respectively. These results suggest that naringin can impart to the adult dopaminergic neurons the ability to produce glial cell line-derived neurotrophic factor against Parkinson's disease with anti-inflammatory effects. Based on these results, we would like to describe an important perspective on its possibility as a therapeutic agent for Parkinson's disease.


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