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RESEARCH AND REPORT
Year : 2014  |  Volume : 9  |  Issue : 16  |  Page : 1520-1524

Transplantation of neurotrophin-3-transfected bone marrow mesenchymal stem cells for the repair of spinal cord injury


Department of Orthopedics, the First Affiliated Hospital of Xinxiang Medical College, Weihui, Henan Province, China

Correspondence Address:
Yuzhen Dong
Department of Orthopedics, the First Affiliated Hospital of Xinxiang Medical University, 88 Jiankanglu, Weihui 453100, Henan Province
China
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Source of Support: This study was supported by Scientific Research Fund of Xinxiang Medical University, No. 2013ZD120; Science and Technology Innovation Talents in Universities in Ministry of Education of Henan Province in 2010, No. 2010HASTIT036., Conflict of Interest: None


DOI: 10.4103/1673-5374.139478

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Bone marrow mesenchymal stem cell transplantation has been shown to be therapeutic in the repair of spinal cord injury. However, the low survival rate of transplanted bone marrow mesenchymal stem cells in vivo remains a problem. Neurotrophin-3 promotes motor neuron survival and it is hypothesized that its transfection can enhance the therapeutic effect. We show that in vitro transfection of neurotrophin-3 gene increases the number of bone marrow mesenchymal stem cells in the region of spinal cord injury. These results indicate that neurotrophin-3 can promote the survival of bone marrow mesenchymal stem cells transplanted into the region of spinal cord injury and potentially enhance the therapeutic effect in the repair of spinal cord injury.


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