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RESEARCH ARTICLE
Year : 2015  |  Volume : 10  |  Issue : 3  |  Page : 432-437

c-Jun N-terminal kinase 3 expression in the retina of ocular hypertension mice: a possible target to reduce ganglion cell apoptosis


1 Department of Ophthalmology, the Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan Province, China
2 Department of Rheumatology and Immunology, the Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan Province, China
3 Department of Ophthalmology, the Second People's Hospital of Zhengzhou City, Zhengzhou, Henan Province, China
4 Department of Ophthalmology, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China

Correspondence Address:
Yue He
Department of Ophthalmology, the Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan Province
China
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Source of Support: This work was supported by grants from the Youth Foundation of Luzhou Medical College of Luzhou City of Sichuan Province of China, No. [2010]108; the Talent Fund of the Affiliated Hospital of Luzhou Medical College of Luzhou City of Sichuan Province of China, No. [2011]43., Conflict of Interest: None


DOI: 10.4103/1673-5374.153692

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Glaucoma, a type of optic neuropathy, is characterized by the loss of retinal ganglion cells. It remains controversial whether c-Jun N-terminal kinase (JNK) participates in the apoptosis of retinal ganglion cells in glaucoma. This study sought to explore a possible mechanism of action of JNK signaling pathway in glaucoma-induced retinal optic nerve damage. We established a mouse model of chronic ocular hypertension by reducing the aqueous humor followed by photocoagulation using the laser ignition method. Results showed significant pathological changes in the ocular tissues after the injury. Apoptosis of retinal ganglion cells increased with increased intraocular pressure, as did JNK3 mRNA expression in the retina. These data indicated that the increased expression of JNK3 mRNA was strongly associated with the increase in intraocular pressure in the retina, and correlated positively with the apoptosis of retinal ganglion cells.


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