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RESEARCH ARTICLE
Year : 2015  |  Volume : 10  |  Issue : 4  |  Page : 576-582

Electrical stimulation of the vagus nerve protects against cerebral ischemic injury through an anti-infammatory mechanism


1 Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China
2 Department of Radiology, Beijing Electric Power Hospit, Beijng, China

Correspondence Address:
Zheng-hui Sun
Department of Neurosurgery, Chinese PLA General Hospital, Beijing
China
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Source of Support: This study was supported by the Beijing Natural Science Foundation of China, No. 7122164., Conflict of Interest: None


DOI: 10.4103/1673-5374.155430

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Vagus nerve stimulation exerts protective effects against ischemic brain injury; however, the underlying mechanisms remain unclear. In this study, a rat model of focal cerebral ischemia was established using the occlusion method, and the right vagus nerve was given electrical stimulation (constant current of 0.5 mA; pulse width, 0.5 ms; frequency, 20 Hz; duration, 30 seconds; every 5 minutes for a total of 60 minutes) 30 minutes, 12 hours, and 1, 2, 3, 7 and 14 days after surgery. Electrical stimulation of the vagus nerve substantially reduced infarct volume, improved neurological function, and decreased the expression levels of tumor necrosis factor-ƒΏ and interleukin- 6 in rats with focal cerebral ischemia. The experimental findings indicate that the neuroprotective effect of vagus nerve stimulation following cerebral ischemia may be associated with the inhibition of tumor necrosis factor-ƒΏ and interleukin-6 expression.


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