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RESEARCH ARTICLE
Year : 2015  |  Volume : 10  |  Issue : 4  |  Page : 610-617

Neuroprotective effect of interleukin-6 regulation of voltage-gated Na+ channels of cortical neurons is time- and dose-dependent


1 Department of Interventional Radiology, First Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong Province, China
2 Department of Neurosurgery, First Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong Province, China
3 Department of Pathogenic Microbiology and Immunology, Shantou University Medical College, Shantou, Guangdong Province, China

Correspondence Address:
Wei-qiang Chen
Department of Neurosurgery, First Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong Province
China
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Source of Support: This work was supported by a grant from the National Natural Science Foundation of China, No. 30972766, 31170852, 81001322, 81172795, 81173048; and the Specialized Research Fund for the Doctoral Program of Colleges and Universities, No. 20094402110004., Conflict of Interest: None


DOI: 10.4103/1673-5374.155436

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Interleukin-6 has been shown to be involved in nerve injury and nerve regeneration, but the effects of long-term administration of high concentrations of interleukin-6 on neurons in the central nervous system is poorly understood. This study investigated the effects of 24 hour exposure of interleukin-6 on cortical neurons at various concentrations (0.1, 1, 5 and 10 ng/mL) and the effects of 10 ng/mL interleukin-6 exposure to cortical neurons for various durations (2, 4, 8, 24 and 48 hours) by studying voltage-gated Na + channels using a patch-clamp technique. Voltage-clamp recording results demonstrated that interleukin-6 suppressed Na + currents through its receptor in a time- and dose-dependent manner, but did not alter voltage-dependent activation and inactivation. Current-clamp recording results were consistent with voltage-clamp recording results. Interleukin-6 reduced the action potential amplitude of cortical neurons, but did not change the action potential threshold. The regulation of voltage-gated Na + channels in rat cortical neurons by interleukin-6 is time- and dose-dependent.


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