Mismatch negativity, social cognition, and functional outcomes in patients after traumatic brain injury
Hui-yan Sun1, Qiang Li2, Xi-ping Chen3, Lu-yang Tao M.D. 3
1 Department of Forensic Medicine, Soochow University, Suzhou, Jiangsu Province; Department of Forensic Medicine, Chifeng University, Chifeng, Inner Mongolia Autonomous Region, China
2 Department of Forensic Medicine, Chifeng University, Chifeng, Inner Mongolia Autonomous Region, China
3 Department of Forensic Medicine, Soochow University, Suzhou, Jiangsu Province, China
Department of Forensic Medicine, Soochow University, Suzhou, Jiangsu Province
Source of Support: This study was supported by grants from the National Natural Science Foundation of China, No. 81172911, 81373251; the National High Technology Research and Development Program of China (863 Program), No. 2015AA020503; the Science and Technology Development Project of Suzhou of China, No. SZP201304; and Priority Academic Program Development of Jiangsu Higher Education Institutes of China., Conflict of Interest: None
Mismatch negativity is generated automatically, and is an early monitoring indicator of neuronal integrity impairment and functional abnormality in patients with brain injury, leading to decline of cognitive function. Antipsychotic medication cannot affect mismatch negativity. The present study aimed to explore the relationships of mismatch negativity with neurocognition, daily life and social functional outcomes in patients after brain injury. Twelve patients with traumatic brain injury and 12 healthy controls were recruited in this study. We examined neurocognition with the Wechsler Adult Intelligence Scale-Revised China, and daily and social functional outcomes with the Activity of Daily Living Scale and Social Disability Screening Schedule, respectively. Mismatch negativity was analyzed from electroencephalogram recording. The results showed that mismatch negativity amplitudes decreased in patients with traumatic brain injury compared with healthy controls. Mismatch negativity amplitude was negatively correlated with measurements of neurocognition and positively correlated with functional outcomes in patients after traumatic brain injury. Further, the most significant positive correlations were found between mismatch negativity in the fronto-central region and measures of functional outcomes. The most significant positive correlations were also found between mismatch negativity at the FCz electrode and daily living function. Mismatch negativity amplitudes were extremely positively associated with Social Disability Screening Schedule scores at the Fz electrode in brain injury patients. These experimental findings suggest that mismatch negativity might efficiently reflect functional outcomes in patients after traumatic brain injury.