• Users Online: 2207
  • Home
  • Print this page
  • Email this page
RESEARCH ARTICLE
Year : 2015  |  Volume : 10  |  Issue : 4  |  Page : 644-650

Exercise promotes motor functional recovery in rats with corticospinal tract injury: anti-apoptosis mechanism


1 Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China
2 Department of Orthopedics, First Clinical Medical College of Three Gorges University, Yichang, Hubei Province, China

Correspondence Address:
Xiao-yu Yang
Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province
China
Login to access the Email id

Source of Support: This study was financially supported by the National Natural Science Foundation of China, No. 81350013., Conflict of Interest: None


DOI: 10.4103/1673-5374.155441

Rights and Permissions

Studies have shown that exercise interventions can improve functional recovery after spinal cord injury, but the mechanism of action remains unclear. To investigate the mechanism, we established a unilateral corticospinal tract injury model in rats by pyramidotomy, and used a single pellet reaching task and horizontal ladder walking task as exercise interventions postoperatively. Functional recovery of forelimbs and forepaws in the rat models was noticeably enhanced after the exercises. Furthermore, TUNEL staining revealed significantly fewer apoptotic cells in the spinal cord of exercised rats, and western blot analysis showed that spinal cord expression of the apoptosis-related protein caspase-3 was significantly lower, and the expression of Bcl-2 was significantly higher, while the expression of Bax was not signifiantly changed after exercise, compared with the non-exercised group. Expression of these proteins decreased with time after injury, towards the levels observed in sham-operated rats, however at 4 weeks postoperatively, caspase-3 expression remained significantly greater than in sham-operated rats. The present findings indicate that a reduction in apoptosis is one of the mechanisms underlying the improvement of functional recovery by exercise interventions after corticospinal tract injury.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1922    
    Printed15    
    Emailed0    
    PDF Downloaded461    
    Comments [Add]    
    Cited by others 5    

Recommend this journal