• Users Online: 2280
  • Home
  • Print this page
  • Email this page
Year : 2016  |  Volume : 11  |  Issue : 12  |  Page : 1956-1961

Subhypnotic doses of propofol impair spatial memory retrieval in rats

First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China

Correspondence Address:
Xue-sheng Liu
First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province
Login to access the Email id

Source of Support: This work was financially supported by the National Natural Science Foundation of China, No. 81571039; the Foundation for Fostering the National Natural Science Foundation of First Affiliated Hospital of Anhui Medical University in China, No. 2015KJ12., Conflict of Interest: None

DOI: 10.4103/1673-5374.197137

Rights and Permissions

Abundant evidence indicates that propofol profoundly affects memory processes, although its specific effects on memory retrieval have not been clarified. A recent study has indicated that hippocampal glycogen synthase kinase-3β (GSK-3β) activity affects memory. Constitutively active GSK-3β is required for memory retrieval, and propofol has been shown to inhibit GSK-3β. Thus, the present study examined whether propofol affects memory retrieval, and, if so, whether that effect is mediated through altered GSK-3β activity. Adult Sprague-Dawley rats were trained on a Morris water maze task (eight acquisition trials in one session) and subjected under the influence of a subhypnotic dose of propofol to a 24-hour probe trial memory retrieval test. The results showed that rats receiving pretest propofol (25 mg/kg) spent significantly less time in the target quadrant but showed no change in locomotor activity compared with those in the control group. Memory retrieval was accompanied by reduced phosphorylation of the serine-9 residue of GSK-3β in the hippocampus, whereas phosphorylation of the tyrosine-216 residue was unaffected. However, propofol blocked this retrieval-associated serine-9 phosphorylation. These findings suggest that subhypnotic propofol administration impairs memory retrieval and that the amnestic effects of propofol may be mediated by attenuated GSK-3β signaling in the hippocampus.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded177    
    Comments [Add]    

Recommend this journal