ORC ID , Long Geng Ph.D., M.D. 2 ORC ID , Hong-bo Zhou2, Hua-chen Wei3, Hong-duo Chen2">
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RESEARCH ARTICLE
Year : 2016  |  Volume : 11  |  Issue : 12  |  Page : 1962-1968

Chinese herbal medicine Yougui Pill reduces exogenous glucocorticoid-induced apoptosis in anterior pituitary cells


1 Department of Dermatology, Second Hospital of Jilin University, Changchun, Jinlin Province, China
2 Department of Dermatology, First Hospital of China Medical University, Shenyang, Liaoning Province, China
3 Department of Dermatology, Mount Sinai Medical Center, New York, USA

Correspondence Address:
Long Geng
Department of Dermatology, First Hospital of China Medical University, Shenyang, Liaoning Province
China
Yong-zhi Ji
Department of Dermatology, Second Hospital of Jilin University, Changchun, Jinlin Province
China
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Source of Support: This study was supported by the National Natural Science Foundation of China, No. 30471576, and 30872277; and a grant from the Innovative Research Program in Universities of the Ministry of Education of China, No. IRT0760., Conflict of Interest: None


DOI: 10.4103/1673-5374.197138

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Long-term glucocorticoid use may result in sustained suppression of one or more secreted components from the hypothalamo-pituitary-adrenal axis, and often results in apoptosis. Yougui Pill (YGP), a 10-component traditional Chinese herbal medicine, has been shown to be clinically effective for glucocorticoid-induced suppression of the hypothalamo-pituitary-adrenal axis. However, the pharmacological and molecular mechanisms remain unclear. We hypothesized that YGP would exert an anti-apoptosis effect on dexamethasone-treated anterior pituitary cells. In vivo experiments showed that YGP significantly reduced the number of apoptotic cells, down-regulated mRNA expression of cytochrome c, caspase-3, and caspase-9, and up-regulated mRNA expression of Bcl-2. These findings suggest that YGP reduced glucocorticoid-induced apoptosis in rat anterior pituitary cells by regulating the mitochondria-mediated apoptosis pathway.


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