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RESEARCH ARTICLE
Year : 2017  |  Volume : 12  |  Issue : 12  |  Page : 2000-2006

Electroacupuncture improves neurovascular unit reconstruction by promoting collateral circulation and angiogenesis


1 First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China
2 National Engineering Research Center for Beijing Biochip Technology, Beijing, China
3 Shaanxi University of Chinese Medicine, Xianyang, Shaanxi Province, China

Correspondence Address:
Zhe-feng Jin
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin
China
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Source of Support: This work was supported by the National Natural Science Foundation of China, No. 81303021, Conflict of Interest: None


DOI: 10.4103/1673-5374.221156

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Acupuncture at Shuigou (GV26) shows good clinical efficacy for treating stroke, but its mechanism remains poorly understood. In this study, a cerebral infarction model of ischemia/reperfusion injury received electroacupuncture at GV26 (15 Hz and 1 mA, continuous wave [biphasic pulses], for 5 minutes). Electroacupuncture effectively promoted regional cerebral blood flow on the infarct and non-infarct sides, increased infarct lesions, lectin, and number of blood vessels, upregulated von Willebrand factor and cell proliferation marker Ki67 expression, and diminished neurological severity score. These findings confirm that electroacupuncture at GV26 promotes establishment of collateral circulation and angiogenesis, and improves neurological function.


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