ORC ID , Huseyin Ustun2, Kamer Kilinc3, Burcak Bilginer1">
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RESEARCH ARTICLE
Year : 2017  |  Volume : 12  |  Issue : 12  |  Page : 2071-2076

Topiramate as a neuroprotective agent in a rat model of spinal cord injury


1 Department of Neurosurgery, Hacettepe University Faculty of Medicine, Ankara, Turkey
2 Department of Pathology, Ankara Training and Research Hospital, Ankara, Turkey
3 Department of Biochemistry, TOBB University of Economics and Technology Faculty of Medicine, Ankara, Turkey

Correspondence Address:
Sahin Hanalioglu
Department of Neurosurgery, Hacettepe University Faculty of Medicine, Ankara
Turkey
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Source of Support: None, Conflict of Interest: All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers' bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript


DOI: 10.4103/1673-5374.221164

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Topiramate (TPM) is a widely used antiepileptic and antimigraine agent which has been shown to exert neuroprotective effects in various experimental traumatic brain injury and stroke models. However, its utility in spinal cord injury has not been studied extensively. Thus, we evaluated effects of TPM on secondary cellular injury mechanisms in an experimental rat model of traumatic spinal cord injury (SCI). After rat models of thoracic contusive SCI were established by free weight-drop method, TPM (40 mg/kg) was given at 12-hour intervals for four times orally. Post TPM treatment, malondialdehyde and protein carbonyl levels were significantly reduced and reduced glutathione levels were increased, while immunoreactivity for endothelial nitric oxide synthase, inducible nitric oxide synthase, and apoptotic peptidase activating factor 1 was diminished in SCI rats. In addition, TPM treatment improved the functional recovery of SCI rats. This study suggests that administration of TPM exerts neuroprotective effects on SCI.


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