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REVIEW
Year : 2018  |  Volume : 13  |  Issue : 7  |  Page : 1151-1155

Factors that modulate olfactory dysfunction


1 School of Biomedical Science, Queensland University of Technology; Institute of Health and Biomedical Innovation, Queensland University of Technology; Clem Jones Centre for Neurobiology and Stem Cell Research, Griffith Institute for Drug Discovery, Griffith University, Brisbane, Queensland, Australia
2 Clem Jones Centre for Neurobiology and Stem Cell Research, Griffith Institute for Drug Discovery; Menzies Health Institute Queensland, Griffith University, Brisbane, Queensland, Australia

Correspondence Address:
Fatemeh Chehrehasa
School of Biomedical Science, Queensland University of Technology; Institute of Health and Biomedical Innovation, Queensland University of Technology; Clem Jones Centre for Neurobiology and Stem Cell Research, Griffith Institute for Drug Discovery, Griffith University, Brisbane, Queensland
Australia
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Source of Support: This work was supported by a grant from the Perry Cross Spinal Research Foundation to FC, JAST and by Queensland University of Technology to FC, Conflict of Interest: None


DOI: 10.4103/1673-5374.235018

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The olfactory system is one of a few areas in the nervous system which is capable of regeneration throughout the life. Olfactory sensory neurons reside in the nasal cavity are continuously replenished with new neurons arising from stem cells. Some factors such as aging, neurodegenerative diseases, head trauma, brain tumor extraction and infection cause olfactory dysfunction which significantly influences physical wellbeing, quality of life, mental health, nutritional status, memory processes, identifying danger and is associated with increased mortality. Therefore, finding a treatment to improve olfactory dysfunction is needed. Recent research efforts in the field have shown some very promising new approaches to treat olfactory dysfunction. This review explores the current studies that have addressed therapeutic approaches to improve olfactory neuron regeneration based on cell transplantation therapy, modulation of physiological olfactory dysfunction and drug treatments.


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