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Year : 2018  |  Volume : 13  |  Issue : 7  |  Page : 1263-1268

Puerarin ameliorates allodynia and hyperalgesia in rats with peripheral nerve injury

Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China

Correspondence Address:
Zhong-Yuan Xia
Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province
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Source of Support: This study was supported by the National Natural Science Foundation of China, No. 81671891, Conflict of Interest: None

DOI: 10.4103/1673-5374.235074

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Puerarin is a major active ingredient of the traditional Chinese plant medicine, Radix Puerariae, and commonly used in the treatment of myocardial and cerebral ischemia. However, the effects of puerarin on neuropathic pain are still unclear. In this study, a neuropathic pain animal model was created by partial sciatic nerve ligation. Puerarin (30 or 60 mg/kg) was intraperitoneally injected once a day for 7 days. Mechanical allodynia and thermal hyperalgesia were examined at 1 day after model establishment. Mechanical threshold and paw withdrawal latency markedly increased in a dose-dependent manner in puerarin-treated rats, especially at 7 days after model establishment. At 7 days after model establishment, quantitative real-time reverse transcriptase-polymerase chain reaction results showed that puerarin administration reversed mRNA expression of transient receptor potential vanilloid 1 (Trpv1) and transient receptor potential ankyrin 1 (Trpa1) in a dose-dependent manner in dorsal root ganglion neurons after peripheral nerve injury. These results suggest that puerarin dose-dependently ameliorates neuropathic pain by suppressing Trpv1 and Trpa1 up-regulation in dorsal root ganglion of neuropathic pain rats.

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