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REVIEW
Year : 2018  |  Volume : 13  |  Issue : 8  |  Page : 1322-1326

Neuroplasticity, limbic neuroblastosis and neuro-regenerative disorders


1 Laboratory of Stem Cells and Neuroregeneration, Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli, Tamil Nadu; Faculty Recharge Programme, University Grants Commission (UGC-FRP), New Delhi, India
2 Institute of Molecular Regenerative Medicine, Salzburg, Paracelsus Medical University; Spinal Cord Injury and Tissue Regeneration Center, Salzburg, Paracelsus Medical University, Salzburg, Austria

Correspondence Address:
Ludwig Aigner
Institute of Molecular Regenerative Medicine, Salzburg, Paracelsus Medical University; Spinal Cord Injury and Tissue Regeneration Center, Salzburg, Paracelsus Medical University, Salzburg, Austria
Austria
Mahesh Kandasamy
Laboratory of Stem Cells and Neuroregeneration, Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli, Tamil Nadu; Faculty Recharge Programme, University Grants Commission (UGC-FRP), New Delhi
India
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Source of Support: This work was supported by the FWF Special Research Program (SFB) F44 (F4413-B23) “Cell Signaling in Chronic CNS Disorders”, and through funding from the European Union’s Seventh Framework Program (FP7/2007-2013) under grant agreements n° HEALTH -F2-2011-278850 (INMiND), n° HEALTH-F2-2011-279288 (IDEA), n° FP7-REGPOT-316120 (GlowBrain); a startup grant from the Faculty Recharge Programme, University Grants Commission (UGC-FRP), New Delhi, India (to MK); a research grant from DST-SERB, New Delhi, India (EEQ/2016/000639) (to MK); an Early Career Research Award (ECR/2016/000741) (to MK), Conflict of Interest: None


DOI: 10.4103/1673-5374.235214

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The brain is a dynamic organ of the biological renaissance due to the existence of neuroplasticity. Adult neurogenesis abides by every aspect of neuroplasticity in the intact brain and contributes to neural regeneration in response to brain diseases and injury. The occurrence of adult neurogenesis has unequivocally been witnessed in human subjects, experimental and wildlife research including rodents, bats and cetaceans. Adult neurogenesis is a complex cellular process, in which generation of neuroblasts namely, neuroblastosis appears to be an integral process that occur in the limbic system and basal ganglia in addition to the canonical neurogenic niches. Neuroblastosis can be regulated by various factors and contributes to different functions of the brain. The characteristics and fate of neuroblasts have been found to be different among mammals regardless of their cognitive functions. Recently, regulation of neuroblastosis has been proposed for the sensorimotor interface and regenerative neuroplasticity of the adult brain. Hence, the understanding of adult neurogenesis at the functional level of neuroblasts requires a great scientific attention. Therefore, this mini-review provides a glimpse into the conceptual development of neuroplasticity, discusses the possible role of different types of neuroblasts and signifies neuroregenerative failure as a potential cause of dementia.


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