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REVIEW
Year : 2018  |  Volume : 13  |  Issue : 8  |  Page : 1342-1345

Current surgical treatments for Parkinson's disease and potential therapeutic targets


Division of Neurosurgery, Toronto Western Hospital, Department of Surgery, University of Toronto, Toronto, Canada

Correspondence Address:
Darrin J Lee
Division of Neurosurgery, Toronto Western Hospital, Department of Surgery, University of Toronto, Toronto
Canada
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1673-5374.235220

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Currently, the most common surgical treatment for Parkinson's disease is deep brain stimulation (DBS). This treatment strategy is typically reserved for bradykinesia, rigidity and tremor in patients who no longer respond to medication in a predictable manner or who suffer medication-induced dyskinesias. In addition to DBS, ablative procedures like radiofrequency, radiosurgery and focused ultrasound are also utilized for select tremor symptoms. In this review, we discuss evolving surgical techniques, targets, and emerging technology. In addition, we evaluate potential paradigm shifts in treatment, including gene therapy, immunotherapy and cell transplantation. While these new techniques and treatment options are still in their infancy, advances in Parkinson's disease treatment are rapidly expanding.


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