ORC ID ">
  • Users Online: 175
  • Home
  • Print this page
  • Email this page
REVIEW
Year : 2018  |  Volume : 13  |  Issue : 8  |  Page : 1346-1349

Amnion epithelial cells – a novel therapy for ischemic stroke?


1 Department of Physiology, Anatomy & Microbiology, La Trobe University, Melbourne, Australia
2 Cardiovascular Disease Program, Department of Pharmacology, Biomedicine Discovery Institute, Monash University, Melbourne, Australia
3 Department of Medicine, Monash University, Melbourne, Australia
4 The Ritchie Centre, Hudson Institute of Medical Research; Department of Obstetrics and Gynaecology, Monash University, Melbourne, Australia

Correspondence Address:
Christopher G Sobey
Department of Physiology, Anatomy & Microbiology, La Trobe University, Melbourne
Australia
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1673-5374.235223

Rights and Permissions

Stroke is a leading cause of death and disability and new therapies are desperately needed. Given the complex nature of ischemic brain injury, it has been postulated that cell-based therapies may be useful. However, cell resources, invasive extraction procedures, immunological rejection, tumorigenesis and ethical challenges make it unlikely that many stem cell types could serve as a practical source for therapy. By contrast, these issues do not pertain to human amnion epithelial cells (hAECs), which are placenta-derived stem cells. We recently assessed the effects of systemically delivered hAECs on stroke outcome using four animal models of stroke. We demonstrated that when injected intravenously after ischemia onset, hAECs migrate preferentially to the spleen and injured brain to limit apoptosis and inflammation, and attenuate early brain infiltration of immune cells, progression of infarction and systemic immunosuppression and to ultimately ameliorate functional deficits. When administration of hAECs is delayed by 1-3 days post-stroke, long-term functional recovery can still be enhanced in young and aged mice of either sex. Moreover, our proof-of-principle findings suggest that hAECs are effective at limiting post-stroke infarct development in non-human primates. Overall, the results suggest that hAECs could be a viable clinical stroke therapy.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2472    
    Printed24    
    Emailed0    
    PDF Downloaded394    
    Comments [Add]    
    Cited by others 12    

Recommend this journal