ORC ID , Li Li2, Jiang-Tao Huo1, Min Cheng1, Lin-Hong Li1">
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RESEARCH ARTICLE
Year : 2018  |  Volume : 13  |  Issue : 8  |  Page : 1384-1389

Effects of repetitive transcranial magnetic stimulation on cognitive function and cholinergic activity in the rat hippocampus after vascular dementia


1 Department of General Medicine & Neurology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei Province, China
2 Department of Pharmacy, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei Province, China

Correspondence Address:
Xiao-Qiao Zhang
Department of General Medicine & Neurology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei Province
China
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Source of Support: This study was supported by a grant from the Major Project of Educational Commission of Hubei Province of China, No. D20152101, Conflict of Interest: None


DOI: 10.4103/1673-5374.235251

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Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive treatment that can enhance the recovery of neurological function after stroke. Whether it can similarly promote the recovery of cognitive function after vascular dementia remains unknown. In this study, a rat model for vascular dementia was established by the two-vessel occlusion method. Two days after injury, 30 pulses of rTMS were administered to each cerebral hemisphere at a frequency of 0.5 Hz and a magnetic field intensity of 1.33 T. The Morris water maze test was used to evaluate learning and memory function. The Karnovsky-Roots method was performed to determine the density of cholinergic neurons in the hippocampal CA1 region. Immunohistochemical staining was used to determine the number of brain-derived neurotrophic factor (BDNF)-immunoreactive cells in the hippocampal CA1 region. rTMS treatment for 30 days significantly improved learning and memory function, increased acetylcholinesterase and choline acetyltransferase activity, increased the density of cholinergic neurons, and increased the number of BDNF-immunoreactive cells. These results indicate that rTMS can ameliorate learning and memory deficiencies in rats with vascular dementia. The mechanism through which this occurs might be related to the promotion of BDNF expression and subsequent restoration of cholinergic system activity in hippocampal CA1 region.


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