ORC ID , Xue-Ping Yu Ph.D. 2 ORC ID , Wei Teng2, Ying Wang4, Wei-Wei Yu2, Hui-Hui Ma2, Qiu-Xin Chen2, Peng Liu1, Rui-Qiao Guan1, Shan-Shan Dong1">
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RESEARCH ARTICLE
Year : 2018  |  Volume : 13  |  Issue : 8  |  Page : 1425-1432

Acupuncture through Baihui (DU20) to Qubin (GB7) mitigates neurological impairment after intracerebral hemorrhage


1 Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China
2 The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China
3 The First Affiliated Hospital of Heilongjiang University of Chinese Medicine; Clinical Key Laboratory of Integrated Traditional Chinese and Western Medicine of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province, China
4 Department of Pharmacology of Dali University, Dali, Yunnan Province, China

Correspondence Address:
Wei Zou
The First Affiliated Hospital of Heilongjiang University of Chinese Medicine; Clinical Key Laboratory of Integrated Traditional Chinese and Western Medicine of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province
China
Xue-Ping Yu
The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province
China
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Source of Support: This study was supported by the National Natural Science Foundation of China, No. 81473764, 81273824; the Key Project of Natural Science Foundation of Heilongjiang Province of China, No. ZD201204; the Doctoral Fund Program of Ministry of Education of China, No. 20102327110003, Conflict of Interest: None


DOI: 10.4103/1673-5374.235298

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Inflammation plays an important role in nerve defects caused by intracerebral hemorrhage. Repairing brain damage by inhibiting the macrophage-inducible C-type lectin/spleen tyrosine kinase (Mincle/Syk) signaling pathway is a potential new target for treating cerebral hemorrhage. In this study, we aimed to determine whether acupuncture through Baihui (DU20) to Qubin (GB7) is an effective treatment for intracerebral hemorrhage through the Mincle/Syk signaling pathway. An intracerebral hemorrhage rat model was established by autologous blood infusion into the caudate nucleus. Acupuncture through Baihui to Qubin was performed for 30 minutes, once every 12 hours, for a total of three times. Piceatannol (34.62 mg/kg), a Syk inhibitor, was intraperitoneally injected as a control. Modified neurological severity score was used to assess neurological function. Brain water content was measured. Immunohistochemistry and western blot assay were used to detect immunoreactivity and protein expression levels of Mincle, Syk, and CARD9. Real-time polymerase chain reaction was used to determine interleukin-1β mRNA levels. Hematoxylin-eosin staining was performed to observe histopathological changes. Our results showed that acupuncture through Baihui to Qubin remarkably improved neurological function and brain water content, and inhibited immunoreactivity and expression of Mincle, Syk, CARD9, and interkeukin-1β. Moreover, this effect was similar to piceatannol. These findings suggest that acupuncture through Baihui to Qubin can improve neurological impairment after cerebral hemorrhage by inhibiting the Mincle/Syk signaling pathway.


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