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  Indian J Med Microbiol
 

Figure 1: Mechanism of action of neuroprotective peptide TFL457. The CPP contains a TrkB-FL juxtamembrane sequence (dark green rectangle) that probably competes a TrkB-interacting protein (orange) important for excitotoxicity-induced endocytosis, thus preventing secondary receptor processing and neuronal death. The interaction of TrkB with this unidentified protein is maintained in the presence of the control peptide TMyc (purple circle) and neuronal death is induced by the excitotoxic insult. CPP: Cell-penetrating peptide; TFL457 and TMyc: Tat-derived CPPs; TrkB: tropomyosin-related kinase B; TrkB-FL: the catalytically active full-length receptor.

Figure 1: Mechanism of action of neuroprotective peptide TFL<sub>457</sub>.
The CPP contains a TrkB-FL juxtamembrane sequence (dark green rectangle) that probably competes a TrkB-interacting protein (orange) important for excitotoxicity-induced endocytosis, thus preventing secondary receptor processing and neuronal death. The interaction of TrkB with this unidentified protein is maintained in the presence of the control peptide TMyc (purple circle) and neuronal death is induced by the excitotoxic insult. CPP: Cell-penetrating peptide; TFL<sub>457</sub> and TMyc: Tat-derived CPPs; TrkB: tropomyosin-related kinase B; TrkB-FL: the catalytically active full-length receptor.