Figure 5: Effect of CEGI on the ultrastructural alterations in infarcted hippocampal CA1 area at 14 days post-MCAO. (A) Electron microscopic images of neuronal necrosis in the hippocampal CA1 region (2550× original magnification). Scale bars: 5 μm. (B) Quantitative analysis of identified necrotic hippocampal neurons. The percentage of necrotic neurons was remarkably reduced in the CEGI-treated rats (P < 0.05). Data are presented as the mean ± SEM (n = 6 per group at each time point). *P < 0.05, vs. MCAO group (Kruskal-Wallis one-way analysis of variance followed by Dunn's post hoc test). CEGI: Cattle encephalon glycoside and ignotin; MCAO: middle cerebral artery occlusion.