Figure 3: Effect of CIMT on the colocalization of NR1 with GluR1/GluR2 in the ipsilateral hippocampus. (A, C) Colocalization of NR1 with GluR2 in the CA1 (A) and CA3 (C) areas of the ipsilateral hippocampus. (B, D) Colocalization of NR1 with GluR1 in the CA1 (B) and CA3 (D) areas of the ipsilateral hippocampus. Confocal images of NR1 (red) and GluR2 (green) and of NR1 (red) and GluR1 (green) double-immunolabeling in the hippocampus are shown in Additional Figures 1–4. Data are expressed as the mean ± SD. *P < 0.05, **P < 0.01 (one-way analysis of variance followed by Tukey's multiple comparisons test). CIMT: Constraint-induced movement therapy; GluR: glutamate receptor; MCAO: middle cerebral artery occlusion.