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  Indian J Med Microbiol
 

Figure 2: Effect of TFHL on histomorphological changes of the injured spinal cord. (A) Assessment of injury in spinal cord sections of different groups using hematoxylin-eosin staining (n = 3 per group, cross-section of the T10 segment of the spinal cord, scale bars: 100 μm). Inflammatory cells and the lesion cavity are clearly visible in each group. The arrows indicate severely injured cavities caused by inflammation. It is worth noting that because of injury or technical reasons, the spinal cord morphology data of the spinal cord injury (SCI) group are incomplete, but this did not affect the observation. (B) The proportion of the lesion cavity area of the total area was determined. The SCI group had the largest proportion of lesion cavity. After 14 days of continuous treatment with TFHL (5, 10, and 20 mg/kg), the proportions of lesion cavity areas of the SCI + TFHL groups decreased with increasing drug concentration. *P < 0.05, vs. sham operation group; #P < 0.05, vs. SCI group; †P < 0.05, vs. SCI + 5 mg/kg TFHL group. Data are expressed as the mean ± SD (one-way analysis of variance followed by a least-significant difference post hoc test). SCI: Spinal cord injury; TFHL: total flavonoids of hawthorn leaves.

Figure 2: Effect of TFHL on histomorphological changes of the injured spinal cord.
(A) Assessment of injury in spinal cord sections of different groups using hematoxylin-eosin staining (<i>n</i> = 3 per group, cross-section of the T10 segment of the spinal cord, scale bars: 100 μm). Inflammatory cells and the lesion cavity are clearly visible in each group. The arrows indicate severely injured cavities caused by inflammation. It is worth noting that because of injury or technical reasons, the spinal cord morphology data of the spinal cord injury (SCI) group are incomplete, but this did not affect the observation. (B) The proportion of the lesion cavity area of the total area was determined. The SCI group had the largest proportion of lesion cavity. After 14 days of continuous treatment with TFHL (5, 10, and 20 mg/kg), the proportions of lesion cavity areas of the SCI + TFHL groups decreased with increasing drug concentration. *<i>P</i> < 0.05, <i>vs</i>. sham operation group; #<i>P</i> < 0.05, <i>vs</i>. SCI group; †<i>P</i> < 0.05, <i>vs</i>. SCI + 5 mg/kg TFHL group. Data are expressed as the mean ± SD (one-way analysis of variance followed by a least-significant difference <i>post hoc</i> test). SCI: Spinal cord injury; TFHL: total flavonoids of hawthorn leaves.