Close
  Indian J Med Microbiol
 

Figure 1: Lineage-traced astrocytes in Aldh1l1-CreERT2 mice crossed with Ai14 mice. (A) Schematic diagram illustrating the experimental design in this study. (B–E) Representative images illustrating astrocytic marker Sox9 among tdTomato (tdT)-labeled cells in non-infected contralateral cortex (B) and NeuroD1-infected side (D). Quantified data are shown in bar graphs (C, ratio of Sox9+ cells among tdT+ cells; E, total Sox9+ cells in local NeuroD1-converted areas or contralateral side). n = 3 for both the control group and the NeuroD1-infected group. *P < 0.05, Student’s t-test. (F–I) Representative images illustrating astrocytic marker GFAP/S100b among tdT-labeled cells in non-infected contralateral cortex (F) and NeuroD1-infected side (H). Quantified data are shown in bar graphs (G, ratio of GFAP+/S100b+ cells among tdTomato+ cells; I, total tdT+ cells in local NeuroD1-converted areas or contralateral side). Scale bar: 20 μm. n = 5 for the control group, n = 3 for the NeuroD1-infected group. **P < 0.01, ***P < 0.001, Student’s t-test. dpi: Day post injection; GFAP: glial fibrillary acidic protein; IHC: immunohistochemistry.

Figure 1: Lineage-traced astrocytes in Aldh1l1-CreER<sup>T2</sup> mice crossed with Ai14 mice. 
(A) Schematic diagram illustrating the experimental design in this study. (B–E) Representative images illustrating astrocytic marker Sox9 among tdTomato (tdT)-labeled cells in non-infected contralateral cortex (B) and NeuroD1-infected side (D). Quantified data are shown in bar graphs (C, ratio of Sox9<sup>+</sup> cells among tdT<sup>+</sup> cells; E, total Sox9<sup>+</sup> cells in local NeuroD1-converted areas or contralateral side). <i>n</i> = 3 for both the control group and the NeuroD1-infected group. *<i>P</i> < 0.05, Student’s <i>t</i>-test. (F–I) Representative images illustrating astrocytic marker GFAP/S100b among tdT-labeled cells in non-infected contralateral cortex (F) and NeuroD1-infected side (H). Quantified data are shown in bar graphs (G, ratio of GFAP<sup>+</sup>/S100b<sup>+</sup> cells among tdTomato<sup>+</sup> cells; I, total tdT<sup>+</sup> cells in local NeuroD1-converted areas or contralateral side). Scale bar: 20 μm. <i>n</i> = 5 for the control group, <i>n</i> = 3 for the NeuroD1-infected group. **<i>P</i> < 0.01, ***<i>P</i> < 0.001, Student’s <i>t</i>-test. dpi: Day post injection; GFAP: glial fibrillary acidic protein; IHC: immunohistochemistry.