Figure 3: Neuroinflammation in the striatum: TSPO expression and GFAP immunoreactivity. (A) Representative total (upper) and nonspecific (lower) binding of [3H]PK-11195 to TSPO in C-ST and I-ST in the control and PHA/PRE groups. (B) Quantification of the specific binding of [3H]PK-11195 in the C-ST and I-ST in both groups. (C) Representative immunostaining of GFAP (red) in C-ST and I-ST in both groups. (D) Quantification of the expression of GFAP (% area occupied) in C-ST and I-ST in the control and PHA/PRE groups. Data are represented as mean ± SD. n = 7/group. *P < 0.05, vs. contralateral area in the same group (Wilcoxon test); #P < 0.05 (Mann-Whitney U test). C-ST: Contralateral striatum; GFAP: glial fibrillary acidic protein; I-ST: ipsilateral striatum; TSPO: 18 kDa translocator protein.