Figure 1: Effect of myricetin on the viability of rotenone-induced MES23.5 cells detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. (A) Exposure of 1 × 10–4 M myricetin alone for 24 hours resulted in decreased viability of MES23.5 cells, whereas 1 × 10–11 M to 1 × 10–5 M myricetin had no effect on cell viability compared with control. (B) Treatment with 400 nM rotenone for 24 hours decreased cell viability compared with the control. Pretreatment with different concentrations of myricetin enhanced cell viability compared with the rotenone group. Data are presented as mean ± SD (n = 6 in A, 12 in B). **P < 0.01, ***P < 0.001, vs. control group; ##P < 0.01, ###P < 0.001, vs. rotenone group (one-way analysis of variance followed by post hoc Tukey’s test).