Figure 7: Schematic diagrams showing signaling pathways involved in myricetin-mediated neuroprotection. (A) By increasing ROS production, rotenone upregulates hepcidin expression via activation of STAT3 and SMAD signaling pathways, thereby inhibiting Fpn1 expression. (B). Myricetin protects against rotenone-induced neurotoxicity by anti-oxidation and suppression of hepcidin expression through inhibition of STAT3 and SMAD signaling. DA: Dopamine; Fpn1: ferroportin 1; p: phosphorylated; ROS: reactive oxygen species; SMAD: mothers against decapentaplegic homolog; STAT3: signal transducer and activator of transcription 3.